6) Some of the children (45%) were taking various types of medications, which did not change during the study. A comparison of the baseline levels of the autism groups taking and not-taking medications revealed little difference between the two groups in their nutritional and metabolic status [20]. There was a trend that the medicated group had less improvement than the unmedicated group in the Average Score of the PGI-R.
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The supplement group improved significantly more than the placebo group on the PGI-R Average Change and on several of the PGI-R subscales. On the PGI-R subscales, the most significant improvements were (in order) in the areas of Hyperactivity, Tantrumming, Overall, and Receptive Language. We hypothesize that longer treatment may result in greater improvements. There was wide variation in degree of improvement, with some participants experiencing little benefit, and some experiencing moderate or substantial benefit.
Serum iron and serum ferritin were similar in the autism and neurotypical groups. A previous study [22] found that 8 of 96 American children with ASD were anemic (haemoglobin 2ff7e9595c
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